To boldly and safely go: Biostatistics in space

Arthritis in space and time--to boldly go!

Despite the profound impact of biologics on the treatment of rheumatoid arthritis (RA), long lasting disease remission remains elusive. We propose that this is a consequence of failing to target the right molecular pathway in the most relevant patient group at the appropriate time and place in disease progression. A limitation to testing this approach is the availability of disease models repre...

To Boldly Go: Bayesian Exploration for Mobile Robots

To BOLDly go where positron emission tomography has been before.

Atherosclerotic disease remains concealed for many years and becomes clinically overt only when the growth of atherosclerotic plaques and the adverse remodeling of the arterial wall reach a critical stage that results in impairment of blood flow, ischemia, and angina. Large epicardial arteries have a diameter ranging from a few millimeters to 500 m and are visible at coronary angiography. Prear...

To Boldly Go Beyond Downloads: How Are Journal Articles Shared and Used?

With more scholarly journals being distributed electronically rather than in print form, we know that researchers download many articles. What is less well known is how journal articles are used after they are initially downloaded. To what extent are they saved, uploaded, tweeted, or otherwise shared? How does this reuse increase their total use and value to research and how does it influence l...

The social brain : allowing humans to boldly go where no other species has been Uta Frith

The biological basis of complex human social interaction and communication has been illuminated through a coming together of various methods and disciplines. Among these are comparative studies of other species, studies of disorders of social cognition and developmental psychology. The use of neuroimaging and computational models has given weight to speculations about the evolution of social be...